If medical advice is needed, have product container or label. It is topically applied to treat melisma, freckles and senile lentigines. Hydroquinone is used to lighten the dark patches of skin also called hyperpigmentation, melasma, liver spots, age spots, freckles caused by. Feb 02, 2016 topical hydroquinone is one of the most popular agents for bleaching the skin for conditions such as melasma or chloasma. In humans, ingestion of 1 gram of hydroquinone has caused tinnitus, nausea, vomiting, shortness of breath, cyanosis, convulsions, delirium, and collapse. Hydroquinone is a phenolic compound, which is naturally found in coffee, tea and wine. Sampling and analytical methods hydroquinone partially. Hydroquinone safety data sheet according to federal register vol. Hydroquinone was not safe for use in leaveon, nondrug cosmetic products. Get medical adviceattention p310 immediately call a poison centerdoctor p330 if swallowed, rinse mouth. May cause dizziness, nausea, sense of suffocation, increased respiratory rate, vomiting, pallor, muscle twitching, cyanosis bluish discoloration of skin due to deficient oxygenation of the blood, delirium.
Oh find msds or sds, a coa, data sheets and more information. Hydroquinone is used to lighten the dark patches of skin also called hyperpigmentation, melasma, liver spots, age spots, freckles caused by pregnancy, birth control pills, hormone medicine. Hydroquinone did not cause birth defects when given orally to pregnant rats at doses up to 300 mgkgday. Chronic occupational exposure to hydroquinone dust has resulted in eye injuries, which varied from mild. It may be found in concentrations up to 15% or more but a doctors prescription is required by the fda united states for. Determination of hydroquinone and mercury concentrations. Suspected of causing cancer very toxic to aquatic life precautionary statements. Hydroquinone, usp hydroquinone, usp sds preparation date 10172016.
All spectrum chemical usp grade products are manufactured, packaged and stored under current good manufacturing practices cgmp per 21cfr part 211 in fda registered and inspected facilities. Page 2 of 14 safety data sheet section 2 hazards identification continued label elements danger hazard statements harmful if swallowed causes skin irritation causes serious eye damage. The optimized condition of nlc in stirring was 1200 rpm, the homogenized. This compound is a generalpurpose inhibitor, stabilizer, antioxidant, and intermediate. This staining is temporary and can typically be removed with soap and water washing, but its best to avoid benzoyl peroxidebased acne treatments and oxygeninfusing skin care treatments, which. Amended safety assessment of hydroquinone as used in. Hydroquinone material safety data sheet cas no 123319. Ac12090, ac120910020, ac120910050, ac120915000, ac219930000, ac219930050 ac219930050, ac219930500, h329500 synonyms. It is formed in large quantities by chemical reduction of benzoquinone. Members of the ectonox family, such as cnox, or enox1, are involved in plasma membrane transport pathways.
The optimized condition of nlc in stirring was 1200 rpm, the homogenized speed was 8000 rpm, solid oil. These enzymes exhibit both a hydroquinone nadh oxidase activity and a protein disulfidethiol interchange activity in series, with each activity cycling every 22 to 26 minutes scarlett et al. Hydroquinone has no known severe, serious, moderate, or mild interactions with other drugs. Your new online msds binder is a place for you to store the material safety data sheets you need to deploy. The mobile phase was a mixture of water and ethanol 45. Clinical director, innovative skincare topical hydroquinone is used frequently throughout the world as a skin bleaching agent. Identification of the substancemixture and of the companyundertaking 1. Topical hydroquinone is one of the most popular agents for bleaching the skin for conditions such as melasma or chloasma. Hydroquinone is a skinbleaching agent that is used to lighten areas of darkened skin such as freckles, melasma, age spots, and acne scars. Hydroquinone for cosmetic use is chemically synthesized. Material safety data sheet eastman chemical company. Osha table z1 limits for air contaminants 29 cfr 1910. Mar 11, 2016 the mean concentration of hydroquinone was 0. Hydroquinone also may be an important factor in the defense mechanis some insects, most notably the bombardier beetle hsdb, 2005 hydroquinone may be released into the environment during its produ.
Show this safety data sheet to the doctor in attendance. The rate of malformations was not significantly increased among the offspring of rabbits administered doses up to 150 mgkgday during pregnancy. The user must determine suitability of this information for his application. Identification and spectrophometric determination of hydroquinone levels in some cosmetic creams article pdf available in african journal of pharmacy and pharmacology 45. Mercury was not detected in most of the creams analyzed, only two samples 1 and 17 contained mercury at a much higher concentration 200 and 100 gg than 1 gg which is the who limit. The dust my cause irritation of the nose, throat and upper respiratory. Melanin is the pigment in skin that gives it a brown color. Due to the irritating nature of both of these agents, topical steroids are commonly added to minimize the inflammation. Hydroquinone 1 section 1 chemical product and company identification msds name. Hydroquinone has been detected in cigarette smoke mainstream and.
Material safety data sheet hydroquinone msds section 1. Acgih threshold limit values 01 2010 pel 2 mgm3 us. If released to soil, hydroquinone may biodegrade under aerobic conditions. Hydroquinone decreases the formation of melanin in the skin. The presence of hydroquinone in normal individuals stems. Occupational exposures to hydroquinone may occur in its production and use in the production of dyes, paints, motor fuels and oils, and some polymers. Sds of hydroquinone, safety data sheets, cas 123319. Final determination of remediation performance to meet regulatory agency requirements was defined by a grid of 26 verticallycomposited soil samples submitted to a certified laboratory for chromium analyses. The frequency of fetal death was increase among rats fed 2500 mgkg of hydroquinone. Alphaarbutin at 2% and 3% each in solution at ph 4.
Pure hydroquinone does not readily form a vapor at room temperature. Safety data sheet vos2 1 product and company identification alliance group, inc. Hydroquinone is a depigmenting agent used to lighten areas of darkened skin such as freckles, age spots, chloasma, and melisma caused by pregnancy, birth control pills, hormone medicine, or injury to the skin. Death has occurred in some individuals after ingestion of 5 grams of hydroquinone. Material safety data sheet hydroquinone 2 ingestion.
A schimadzu lc9 was used with uv detector set at 295 nm having ods column 25 cm. Melanin is the pigment in skin that gives it a brown color hydroquinone is available under the following. May cause severe irritation of the digestive tract. It is used in photographic, chemical and cosmetic industries. Nanostructured lipid carrier nlc was prepared by homogenization emulsification method and improved with modified surfactants. Chemical product and company identification product name.
Disclaimer the sds samples above are collected from the internet by chemblink and displayed here for the tutorial purpose only. In situ remediation of chromium in soil and groundwater. Dermal contact with hydroquinone may occur in the development of blackandwhite photographs. Hydroquinone topical is used to lighten areas of darkened skin such as freckles, age spots, chloasma, and melasma. Pdf identification and spectrophometric determination of. Safety data sheet according to 29cfr19101200 and ghs rev. Hydroquinone after initiation increased the multiplicity of foci from 0. Opinion of the scientific committee on consumer safety on. It may be released to the environment as a fugitive emission during its production, formulation, and use, as a chemical intermediate, photographic chemical, and stabilizer. Use of hydroquinone with any products containing benzoyl peroxide, hydrogen peroxide, or other peroxides may cause temporary staining of the skin. It is frequently combined with retina to enhance its bleaching effects.
The properties of nanoparticles were investigated using the nlc system for hydroquinone hq as a model drug and by increasing the light stability of hydroquinone. Material safety data sheet hydroquinone 6 information in this msds is from available published sources and is believed to be accurate. Some doctors offices may sell other brands with concentrations up to 4%. Hydroquinone is a white crystalline solid that is soluble in water.
Hydroquinone is a skin, eye, mucous membrane, and gastrointestinal irritant. Hydroquinone is an active allergen so repeated and. While this only occurs when the eye is directly exposed to hydroquinone, it is still a risk factor. Hydroquinone is commonly used as a biomarker for benzene exposure. Qualitative and quantitative estimation of hydroquinone in. Mercury and hydroquinone content of skin toning creams and. All the creams and soaps analysed had mercury and hydroquinone levels below the us food and drug administrations acceptable limit of 1. Jun 03, 2014 despite popular belief that hydroquinone may cause cancer, hydroquinones most serious human health effect is pigmentation of the eye and permanent corneal damage journal of the european academy of dermatology and venearology, 2006. Hydroquinone, usp is an effective topical medicine used to treat dark colored patches, freckles, and spots on the skin that appear due to sun exposure. Hydroquinone is linked to exogenous ochronosis, dermatitis and skin. This information does not contain all possible interactions or adverse effects.
First aid measures description of first aid measures. In a second experiment, groups of 10 rats underwent the regimen to initiate liver carcinogenesis and received 0 or 1 mgkg bw. Hydroquinone is both a natural and an anthropogenic compound. Opinion of the scientific committee on consumer safety on o. Sigmaaldrich material safety data sheet date printed. Hydroquinone, 123319, laboratory chemicals, c6h6o2 by loba chemie, india. First aid measures description of firstaid measures general advice. No warranty, express or implied, is made and qorpak assumes no liability resulting from the use of this msds.
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